D-Dimer Concentrations and Thromboelastography in Five Dogs With Ischemic Stroke
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D-Dimer Concentrations and Thromboelastography in Five Dogs With Ischemic Stroke. / Koch, Bodil Cathrine; Motta, Luca; Wiinberg, Bo; Westrup, Ulrik; Kristensen, Annemarie Thuri; Skerritt, Geoff; Berendt, Mette; Gredal, Hanne.
In: Frontiers in Veterinary Science, Vol. 6, 255, 2019.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - D-Dimer Concentrations and Thromboelastography in Five Dogs With Ischemic Stroke
AU - Koch, Bodil Cathrine
AU - Motta, Luca
AU - Wiinberg, Bo
AU - Westrup, Ulrik
AU - Kristensen, Annemarie Thuri
AU - Skerritt, Geoff
AU - Berendt, Mette
AU - Gredal, Hanne
PY - 2019
Y1 - 2019
N2 - Ischemic stroke is a condition increasingly recognized in dogs; however, the number of publications on dogs with ischemic stroke is still limited and hemostatic parameters are infrequently reported. D-dimer levels have been shown to be elevated in people with acute ischemic stroke compared to a healthy control population and it has been proposed that a normal D-dimer can be used to exclude thromboembolism in dogs. In this case series, we report hemostatic parameters, including D-dimer and thromboelastography (TEG) along with clinical and imaging findings for five dogs diagnosed with ischemic stroke. All dogs had a normal D-dimer concentration on presentation. A hypercoagulable state was identified in two dogs based on the results of the TEG, and was suspected in the remaining three cases based on a shortened TEG clot reaction time. Based on the findings in the present cases, a D-dimer within the normal reference range does not seem an appropriate negative predictor for canine ischemic stroke. The demonstration of a possible hypercoagulable state, as identified by the TEG, is an interesting finding which should be explored further to help reveal predisposing hypercoagulable conditions in dogs with ischemic stroke.
AB - Ischemic stroke is a condition increasingly recognized in dogs; however, the number of publications on dogs with ischemic stroke is still limited and hemostatic parameters are infrequently reported. D-dimer levels have been shown to be elevated in people with acute ischemic stroke compared to a healthy control population and it has been proposed that a normal D-dimer can be used to exclude thromboembolism in dogs. In this case series, we report hemostatic parameters, including D-dimer and thromboelastography (TEG) along with clinical and imaging findings for five dogs diagnosed with ischemic stroke. All dogs had a normal D-dimer concentration on presentation. A hypercoagulable state was identified in two dogs based on the results of the TEG, and was suspected in the remaining three cases based on a shortened TEG clot reaction time. Based on the findings in the present cases, a D-dimer within the normal reference range does not seem an appropriate negative predictor for canine ischemic stroke. The demonstration of a possible hypercoagulable state, as identified by the TEG, is an interesting finding which should be explored further to help reveal predisposing hypercoagulable conditions in dogs with ischemic stroke.
KW - ischemic stroke
KW - infarction
KW - cerebrovascular accident
KW - hemostatic parameters
KW - D-dimer
KW - hypercoagulability
KW - thromboelastography
KW - TEG
U2 - 10.3389/fvets.2019.00255
DO - 10.3389/fvets.2019.00255
M3 - Journal article
C2 - 31448295
VL - 6
JO - Frontiers in Veterinary Science
JF - Frontiers in Veterinary Science
SN - 2297-1769
M1 - 255
ER -
ID: 226786367